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https://ninho.inca.gov.br/jspui/handle/123456789/8252
Title: | Gasoline-station workers in Brazil: benzene exposure; Genotoxic and immunotoxic effects |
Authors: | Poça, Katia Soares da Giardini, Isabela Silva, Paula Vieira Baptista da Geraldino, Barbara Rodrigues Bellomo, Antonella Alves, Julia Araújo Conde, Taline Ramos Zamith, Helena Pereira da Silva Otero, Ubirani Barros Ferraris, Fausto Klabund Friedrich, Karen Mello, Marcia Sarpa de Campos |
Keywords: | Exposição Ocupacional Occupational Exposure Exposición Profesional Exposição por Inalação Inhalation Exposure Exposición por Inhalación Benzeno Benzene Benceno Posto de Combustível Filling Station Gasolineras Dano ao DNA DNA Damage Daño del ADN |
Issue Date: | 2021 |
Publisher: | Mutation Research - Genetic Toxicology and Environmental Mutagenesis (MRGTEM) |
Citation: | POÇA, Katia Soares da et al. Gasoline-station workers in Brazil: Benzene exposure; Genotoxic and immunotoxic effects, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, v. 865, 2021. ISSN 1383-5718. Disponível em: https://doi.org/10.1016/j.mrgentox.2021.503322. |
Abstract: | Chronic exposure to benzene is a risk factor for hematological malignancies. Gasoline-station workers are exposed to benzene in gasoline, via both inhalation and dermal contact (attendants and managers) or inhalation (workers in the on-site convenience stores and offices). We have studied the exposure of these workers to benzene and the resulting genotoxic and immunotoxic effects. Levels of urinary trans, trans-muconic acid were higher among gasoline-station workers than among office workers with no known exposure to benzene (com-parison group). Among the exposed workers, we observed statistically significant biological effects, including elevated DNA damage (comet assay); higher frequencies of micronuclei and nuclear buds (CBMN assay); lower levels of T-helper lymphocytes and naive Th lymphocytes; lower CD4 / CD8 ratio; and higher levels of NK cells and memory Th lymphocytes. Both groups of exposed workers (inhalation and inhalation + dermal routes) showed similar genotoxic and immunotoxic effects. |
Description: | v. 1, 9 p.: il. color. |
URI: | http://sr-vmlxaph03:8080/jspui/handle/123456789/8252 |
ISSN: | 1383-5718 |
Appears in Collections: | Artigos de Periódicos da área da Vigilância do Câncer Relacionado ao Trabalho e ao Ambiente Marcia Sarpa de Campos Mello |
Files in This Item:
File | Description | Size | Format | |
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Gasoline-station workers in Brazil.pdf | 1.22 MB | Adobe PDF | View/Open |
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