Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/9788
Title: Effects of ageing and pharmacological hypothyroidism on pituitary-thyroid axis of Dutch-Miranda and Wistar rats
Authors: Moreira, Debora Galvao
Marassi, Michelle Porto
Costa, Vânia Maria Corrêa da
Carvalho, Denise Pires de
Rosenthal, Doris
Keywords: Thyroid Hormones
Hormonas Tiroideas
Thyrotropin
Tireotropina
Aging
Envelhecimento
Hypothyroidism
Hipotireoidismo
Rats
Ratos
Methimazole
Metimazol
Issue Date: 2005
Publisher: Experimental Gerontology
Citation: MOREIRA, Debora Galvao et al. Effects of ageing and pharmacological hypothyroidism on pituitary-thyroid axis of Dutch-Miranda and Wistar rats. Experimental Gerontology, v. 40, p. 330–334, 2005.
Abstract: To evaluate the ability of the aged rat pituitary to increase TSH secretion in response to major decreases in serum thyroid hormones, hypothyroidism was induced by methimazole in young and old, male and female, Dutch-Miranda and Wistar rats. Before MMI-treatment there were no differences in serum TSH of young and old rats, but serum T4 was significantly decreased in aged rats from both genders and strains, while serum T3 was significantly decreased in aged male rats from both strains, and in old Wistar females. MMI treatment significantly decreased serum T4 and T3 in all treated animals, and progressively increased serum TSH in both male and female rats, but the increase was significantly smaller in the elder rats. The pituitary TSH content was higher in Wistar than in Dutch-Miranda rats, of both genders, and was not significantly affected by age. MMI treatment decreased the pituitary TSH in both young and old Dutch-Miranda rats, but in the Wistar strain only the old females had a significant decrease. Our results show that the ability of the pituitary thyrotrophs to increase hormonal secretion in response to decreased levels of thyroid hormones is impaired in the old rat, even when the thyroid hormone levels are dramatically reduced.
Description: p. 330–334.: il. p&b.
URI: http://sr-vmlxaph03:8080/jspui/handle/123456789/9788
ISSN: 1873-6815
Appears in Collections:Artigos de Periódicos da área de Enfermagem



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